TL;DR

If weight loss feels resistant despite healthy habits, your genes and nutrient status may be the missing link. Nutrigenetic testing reveals how detox pathways, thyroid support, and nutrient metabolism impact fat loss allowing for a personalized plan that supports metabolism, energy, and long-term weight management.

Key Takeaways

• Weight loss resistance is often genetic, not willpower related.
• Nutrigenetics identifies hidden metabolic and detox roadblocks that can prevent fat loss.
• Micronutrient deficiencies and genetic variants impact thyroid function, insulin sensitivity, and energy.
• Supporting detox and antioxidant pathways (like glutathione) improves metabolic efficiency.
• Personalized nutrition removes guesswork, making weight loss more sustainable and effective.
  
  

What is Nutrigenetics?

Nutrigenetics is a branch of science that examines the relationship between your genetic makeup and how your body responds to nutrients. It helps explain why two people can eat the same diet yet experience very different outcomes especially when it comes to energy levels, inflammation, and weight management.

Your genes influence how you digest, absorb, metabolize, and utilize nutrients, as well as how efficiently your body detoxifies, regulates blood sugar, and produces energy. By understanding these genetic variations, we can create highly personalized nutrition and supplement strategies that optimize metabolism, support sustainable weight loss, and reduce the risk of chronic disease.

How I Use Nutrigenetics in Practice

In my practice, I combine Micronutrient Testing with Genetic Vitamin Markers to gain a deeper understanding of what your body truly needs. Micronutrient testing reveals how well your body is absorbing and utilizing essential vitamins, minerals, antioxidants, and amino acids. When paired with genetic testing, we can identify inherited tendencies that may affect:

• Detoxification pathways
• Oxidative stress levels
• Nutrient transport and absorption
• Inflammation and insulin sensitivity

These factors often play a hidden role in stubborn weight gain, fatigue, hormone imbalance, and metabolic resistance, even when labs appear “normal” and healthy habits are in place. If you’ve been doing “all the right things” but still struggle with weight loss or low energy, this testing provides clarity at the root-cause level.

The Micronutrient Panel with Genetics

This comprehensive approach allows us to design a plan that supports fat metabolism, cellular energy, and long-term wellness by:

• Identifying genetic variations that influence vitamin, mineral, and fatty acid metabolism
• Measuring key nutrient levels alongside genetic predispositions
• Detecting early imbalances before they contribute to chronic inflammation, metabolic dysfunction, or disease

The result is a personalized nutrition and supplementation plan designed to optimize metabolism, improve energy, and support healthy weight loss.

Key Detoxification Genes That May Impact Weight Loss

Glutathione: The Master Detox Antioxidant plays a critical role in:

• Liver detoxification
• Reducing oxidative stress and inflammation
• Supporting insulin sensitivity
• Enhancing mitochondrial energy (ATP production)
• Promoting metabolic efficiency and weight regulation

When glutathione levels are low, the body may struggle to detoxify efficiently, which can contribute to metabolic slowdown and weight resistance.

Key Glutathione Genes:

GSS Gene
This gene provides instructions for producing glutathione. Certain genetic variations can reduce enzyme activity, leading to lower glutathione levels and increased oxidative stress.

GSTP1 Gene
This gene supports detoxification by helping neutralize harmful compounds. Variations may reduce enzyme activity, increasing cellular damage and detox burden.

Individuals with these variations often benefit from glutathione-supportive foods such as:

• Mushrooms, spinach, avocados, okra
• Cruciferous vegetables
• High-quality animal proteins and dairy (yogurt, cottage cheese)
  Targeted supplementation may also be beneficial, depending on test results.

Selenium: Thyroid Support & Metabolic Health

Selenium is a trace mineral essential for thyroid hormone conversion, specifically the conversion of inactive T4 to active T3. Because thyroid hormones regulate metabolic rate, selenium plays a vital role in:

• Energy production
• Fat metabolism
• Antioxidant protection
• Healthy weight maintenance

Selenium is also a key component of glutathione peroxidase, an enzyme that protects cells from oxidative damage and supports detoxification.

Key Selenium Genes:

GPX1 Gene
Variations can impair antioxidant defense, increasing oxidative stress and disease risk.

SEPP1 Gene
This gene is responsible for transporting selenium into tissues. Certain variants may reduce selenium delivery to key organs, increasing the risk of deficiency and metabolic imbalance.

Individuals with higher genetic risk may benefit from selenium-rich foods such as:

• Brazil nuts
• Seafood (oysters, tuna, shrimp, halibut)
• Eggs, chicken, beef, pork, cottage cheese

Because excess selenium can be harmful, testing is essential before supplementing.

Why This Matters for Weight Loss

When nutrient deficiencies, detox impairments, or genetic metabolic blocks go unaddressed, the body may prioritize survival over fat loss. By correcting these imbalances, we can help your body:

• Improve insulin sensitivity
• Reduce inflammation
• Support thyroid and liver function
• Increase energy and metabolic efficiency

Weight loss is not one-size-fits-all. When your genes, nutrient status, and detox pathways are working against you, traditional approaches often fail. The Micronutrient Panel with Genetics helps identify what’s holding your metabolism back so we can create a targeted plan that supports fat loss, energy, and hormone balance.

Book your consultation today or contact us to order your lab test and take the guesswork out of weight loss with personalized, data-driven care allowing for long term weight management. Questions? Call or Text us: 317-344-9840